Legal Documentation

Terms of Use &
Intellectual Property Rights

Effective Date: January 1, 2026  ·  Version: 1.0
Governing Platform: Aurelyn Clinical Engines™ & Aurelyn Trial | OS™
Issuing Entity: Aurelyn AI Clinical  ·  [email protected]

Definitions

The following terms, as used throughout this Agreement, shall have the meanings set forth below. Capitalized terms used but not defined herein carry the meaning ascribed to them in applicable context.

"Aurelyn AI Clinical" The legal entity that owns, develops, operates, and maintains the Aurelyn Clinical Engines™ platform, Aurelyn Trial | OS™, and all associated services, software, systems, and intellectual property. Also referred to herein as "Company," "we," "us," or "our."
"Platform" The combined B2B clinical AI platform consisting of the Aurelyn Clinical Engines™ suite — including the eTMF Intelligence Engine and the Clinical Evidence Engine — and the Aurelyn Trial | OS™ operating environment, together with all associated APIs, dashboards, integrations, software components, AI models, and services.
"Aurelyn Clinical Engines™" The proprietary, dual-engine AI framework comprising the eTMF Intelligence Engine and the Clinical Evidence Engine, designed to deliver unified clinical intelligence across sponsors, CROs, and life sciences organizations. All engine logic, AI pipelines, classification models, and compliance layers are exclusively proprietary to Aurelyn AI Clinical.
"Aurelyn Trial | OS™" The proprietary clinical trial operating system that provides the unified intelligence architecture, AI Core, compliance infrastructure, and workflow orchestration layer that integrates the Aurelyn Clinical Engines™ with the client's trial technology stack.
"eTMF Intelligence Engine" The AI-driven engine built on the CDISC eTMF Reference Model that continuously ingests, classifies, and monitors trial master file documents, providing audit readiness scoring, gap detection, and automated site notifications.
"Clinical Evidence Engine" The AI-driven engine that aggregates and synthesizes clinical evidence from across the trial technology stack — including EDC, IRT, CTMS, ePRO, safety databases, and central labs — to surface endpoints, safety signals, and submission-ready evidence packages.
"User" / "Client" Any individual, organization, sponsor, CRO, biotech, or life sciences entity that accesses, evaluates, or uses the Platform pursuant to a valid executed agreement or authorized access grant from Aurelyn AI Clinical.
"Agreement" These Terms of Use, together with any executed Master Services Agreement, Partnership Agreement, Order Form, Business Associate Agreement, or Data Processing Agreement between the User and Aurelyn AI Clinical.
"AI Output" Any data, classification, score, analysis, synthesis, narrative, report, insight, alert, or other result generated by the Platform's artificial intelligence and machine learning models in response to trial data inputs.
"Trial Data" Any clinical, regulatory, documentary, or operational data submitted to or processed by the Platform by or on behalf of the User in connection with the User's clinical trial operations.
"Confidential Information" Any non-public technical, business, regulatory, financial, or operational information disclosed by either party in connection with the Agreement, including all Platform architecture, AI model weights, training data, pricing, and client trial data.

Acceptance of Terms

Important Notice

By accessing, evaluating, integrating, or using any component of the Platform — including participation in a live demonstration, proof of concept, pilot program, or production deployment — the User agrees to be bound by these Terms in their entirety. If you are accessing the Platform on behalf of an organization, you represent and warrant that you have authority to bind that organization.

Access to the Platform is restricted to authorized Users under a valid executed agreement. Unauthorized access, use, reproduction, or distribution of any Platform component is strictly prohibited and may give rise to civil and criminal liability.

These Terms govern all interactions with the Platform, including but not limited to: API access, dashboard use, document ingestion, AI Output consumption, system integrations, and any derived reporting or analytics activities.

Platform Overview

The Platform consists of two purpose-built AI engines that converge into a single unified intelligence architecture — the Aurelyn Trial | OS™ — continuously monitoring, classifying, and surfacing insights across the User's clinical trial technology stack.

📄
eTMF Intelligence Engine
Engine 01 · Proprietary

AI-driven document ingestion, auto-classification against CDISC eTMF Reference Model zones and artifacts, continuous monitoring for audit gaps, predictive readiness scoring, and automated site notifications.

🔬
Clinical Evidence Engine
Engine 02 · Proprietary

Real-time endpoint tracking, safety signal detection, CDISC-aligned evidence synthesis across EDC, CTMS, IRT, safety databases and central labs, and submission-ready evidence package assembly.

The Platform is designed for use by sponsors, CROs, and AI-forward biotechs operating clinical trials subject to 21 CFR Part 11, FDA, ICH/GCP (E6(R2)), HIPAA, GDPR, and related regulatory requirements. Aurelyn AI Clinical does not warrant that Platform use alone constitutes regulatory compliance; Users retain responsibility for their regulatory obligations.

License Grant & Restrictions

Subject to the User's compliance with this Agreement and payment of applicable fees, Aurelyn AI Clinical grants the User a limited, non-exclusive, non-transferable, non-sublicensable, revocable license to access and use the Platform solely for the User's internal clinical trial operations during the applicable subscription term.

This license expressly excludes the right to:

Activity Authorized Users Third Parties Competitors
Access Platform dashboards & APIs ✓ Permitted ✗ Prohibited ✗ Prohibited
Use AI Output in internal reports ✓ Permitted Restricted ✗ Prohibited
Submit AI Output to regulators ✓ Permitted N/A N/A
Reproduce or redistribute Platform ✗ Prohibited ✗ Prohibited ✗ Prohibited
Reverse engineer AI models ✗ Prohibited ✗ Prohibited ✗ Prohibited
Use to train external AI systems ✗ Prohibited ✗ Prohibited ✗ Prohibited

Intellectual Property Rights

Ownership Declaration

All intellectual property comprising or embedded in the Platform — including the Aurelyn Clinical Engines™ and Aurelyn Trial | OS™ — is and shall remain the sole and exclusive property of Aurelyn AI Clinical. No rights are transferred to the User except the limited license expressly granted in § 04.

Aurelyn AI Clinical's intellectual property includes, without limitation:

User Data Ownership. The User retains all rights to Trial Data submitted to the Platform. The User grants Aurelyn AI Clinical a limited, non-exclusive license to process Trial Data solely as necessary to operate and deliver the Platform services. Aurelyn AI Clinical shall not use Trial Data to train models for deployment to other clients except in anonymized, aggregated, de-identified form in accordance with applicable law and the executed Data Processing Agreement.

AI Output Ownership. AI Outputs are generated by Aurelyn AI Clinical's proprietary models. The User receives a license to use AI Outputs for its internal clinical operations and regulatory submissions. Aurelyn AI Clinical retains all underlying model and methodology rights. The User shall not represent AI Outputs as independently developed analytical conclusions without appropriate attribution to the Platform.

Trademarks & Brand Identity

The following marks are proprietary trademarks and service marks of Aurelyn AI Clinical, whether registered or unregistered:

Aurelyn Clinical Engines™

The dual-engine clinical AI platform brand and all associated engine identities, product names, and commercial designations.

Aurelyn Trial | OS™

The proprietary clinical trial operating system brand, including all associated platform names, logos, and product identifiers.

Additional protected marks and designations include: Aurelyn AI Clinical®, TMF Completeness Index™, eTMF Intelligence Engine™, Clinical Evidence Engine™, and any other product names, slogans, or design elements associated with the Platform.

Users are prohibited from:

Authorized Users may identify themselves as a licensed user of the Aurelyn Clinical Engines™ platform in limited factual contexts, using only the unmodified marks and subject to any brand guidelines provided by Aurelyn AI Clinical.

Data, Privacy & Regulatory Compliance

The Platform is designed with compliance at its core, incorporating architectural controls for the following frameworks. Compliance certifications and control documentation are available upon request under a Non-Disclosure Agreement:

21 CFR Part 11 Electronic records and signatures — audit trails, access controls, system validation, and electronic signature controls are embedded across all Platform data flows and document processing workflows.
FDA AI/ML Guidance Platform AI systems are designed with transparency, explainability, and human-in-the-loop oversight principles consistent with FDA guidance on artificial intelligence and machine learning in drug development.
ICH E6(R2) — GCP Good Clinical Practice principles govern all trial data handling, subject data protection, and investigator site interaction workflows within the Platform.
HIPAA Protected Health Information (PHI) safeguards, encryption at rest and in transit, role-based access controls, and Business Associate Agreement (BAA) readiness are standard Platform features.
GDPR / EU Privacy Data minimization, consent tracking, right-to-erasure support, data processing agreements, and EU data residency options are available. Aurelyn AI Clinical maintains a Data Processing Agreement for all EU-subject data.
CDISC Standards Full alignment with CDISC eTMF Reference Model, CDASH, SDTM, and ADaM standards for interoperability and regulatory submission readiness across FDA, EMA, PMDA, and other regulatory authorities.
Regulatory Responsibility

While the Platform incorporates extensive compliance controls, Users retain ultimate responsibility for their own regulatory compliance obligations. AI Outputs, including audit readiness scores, evidence syntheses, and regulatory packages, should be reviewed by qualified clinical, medical, and regulatory professionals prior to submission to or reliance upon by any regulatory authority.

Prohibited Uses

In addition to the restrictions in § 04, Users shall not use the Platform to:

Disclaimers & Warranties

Disclaimer of Warranties

THE PLATFORM AND ALL AI OUTPUTS ARE PROVIDED "AS IS" AND "AS AVAILABLE." AURELYN AI CLINICAL MAKES NO WARRANTIES, EXPRESS OR IMPLIED, INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NON-INFRINGEMENT, OR REGULATORY COMPLIANCE. AURELYN AI CLINICAL DOES NOT WARRANT THAT THE PLATFORM WILL BE ERROR-FREE, UNINTERRUPTED, OR FREE FROM CYBERSECURITY THREATS.

Aurelyn AI Clinical warrants that: (i) the Platform will perform materially in accordance with its documentation under normal use conditions; (ii) Aurelyn AI Clinical will implement commercially reasonable security measures; and (iii) Aurelyn AI Clinical has the right to grant the licenses provided herein.

AI Outputs are generated by probabilistic models and do not constitute medical advice, legal advice, or regulatory determinations. Users bear full responsibility for human review, validation, and professional judgment applied to all AI Outputs before clinical, regulatory, or operational reliance.

Limitation of Liability

TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, AURELYN AI CLINICAL SHALL NOT BE LIABLE FOR ANY INDIRECT, INCIDENTAL, SPECIAL, CONSEQUENTIAL, PUNITIVE, OR EXEMPLARY DAMAGES ARISING FROM OR RELATED TO THE PLATFORM OR THESE TERMS, INCLUDING DAMAGES FOR LOSS OF DATA, REGULATORY FINDINGS, TRIAL DELAYS, PROFITS, OR GOODWILL.

AURELYN AI CLINICAL'S TOTAL CUMULATIVE LIABILITY ARISING OUT OF OR RELATED TO THESE TERMS SHALL NOT EXCEED THE GREATER OF: (i) THE TOTAL FEES PAID BY THE USER TO AURELYN AI CLINICAL IN THE TWELVE (12) MONTHS IMMEDIATELY PRECEDING THE CLAIM; OR (ii) ONE THOUSAND US DOLLARS ($1,000).

The limitations set forth in this section shall apply even if Aurelyn AI Clinical has been advised of the possibility of such damages. Some jurisdictions do not permit the exclusion of certain implied warranties or limitation of certain damages; in such jurisdictions, limitations shall apply to the fullest extent permitted by law.

Indemnification

The User shall defend, indemnify, and hold harmless Aurelyn AI Clinical and its officers, directors, employees, agents, licensors, and partners from and against any claims, liabilities, damages, losses, costs, and expenses (including reasonable legal fees) arising out of or related to:

Aurelyn AI Clinical shall indemnify the User against third-party claims that the Platform, as delivered, infringes any valid patent, copyright, or trade secret, subject to the User promptly notifying Aurelyn AI Clinical of any such claim and cooperating fully in the defense.

Governing Law & Disputes

This Agreement shall be governed by and construed in accordance with the laws of the United States and the State of Delaware, without regard to conflict of laws principles. The United Nations Convention on Contracts for the International Sale of Goods (CISG) shall not apply.

Dispute Resolution. The parties agree to first attempt resolution of any dispute through good-faith negotiation for a period of thirty (30) days from written notice of the dispute. If unresolved, disputes shall be submitted to binding arbitration under the Commercial Arbitration Rules of the American Arbitration Association (AAA), with proceedings conducted in English in Wilmington, Delaware, before a single arbitrator. The arbitrator's award shall be final and may be entered as a judgment in any court of competent jurisdiction.

Equitable Relief. Notwithstanding the foregoing, either party may seek emergency injunctive or other equitable relief in any court of competent jurisdiction to prevent irreparable harm, including enforcement of intellectual property rights or confidentiality obligations, without waiving the right to arbitration.

Class Action Waiver. All disputes shall be resolved on an individual basis; class actions, class arbitrations, and consolidated proceedings are not permitted.

Modifications

Aurelyn AI Clinical reserves the right to modify these Terms at any time. Material changes will be communicated to Users via: (i) notice posted to the Platform; (ii) email to the User's registered contact address; or (iii) updated version posting at the official platform URL with a revised effective date.

Continued use of the Platform following the effective date of modified Terms constitutes acceptance of such modifications. Users who do not agree to material changes may terminate their agreement in accordance with the applicable notice period in their executed services agreement.

Aurelyn AI Clinical also reserves the right to modify, update, or discontinue any feature, engine, integration, or component of the Platform at any time upon reasonable notice, provided that core contracted functionality is maintained through the applicable subscription term.

Contact & Legal Notices

All legal notices, IP rights inquiries, trademark permissions, data privacy requests, and compliance inquiries should be directed to:

Legal & IP Inquiries [email protected]
Privacy & Data Requests [email protected]
Partnership & Licensing [email protected]

Aurelyn Clinical Engines™ · Aurelyn Trial | OS™

These Terms constitute the complete agreement between Aurelyn AI Clinical and the User with respect to Platform use and intellectual property rights, superseding all prior discussions, representations, and agreements on the subject matter hereof.

EFFECTIVE DATE: JANUARY 1, 2026 · VERSION 1.0 · © 2026 AURELYN AI CLINICAL